ニュース＆トピックス
セミナーのお知らせ:Robert Murray氏 (Associate Professor, Department of Physics, Faculty of Natural Sciences, Imperial College London)
以下のとおりセミナーを開催いたします。皆様のご参加をお待ちしています。
UTriplセミナー
・ALICeセミナー
GMSIセミナー
・WINGS CFSセミナー
TACMIコンソーシアムオープンセミナー
日時：２０２６年４月２０日（月）13:30～14:30
場所：東京大学理学部1号館3階381号室（対面のみ）
講演者：Robert Murray 氏
(Associate Professor, Department of Physics, Faculty of Natural Sciences, Imperial College London)
講演題目:Mid-Infrared Laser Ablation for Mass Spectrometry Imaging at Sub-cellular Scales
Abstract
Mass spectrometry imaging (MSI) is emerging as a transformative technique for spatial biology, multi-omics, and clinical pathology. Unlike traditional optical microscopy, which visualizes cells and tissues with photons, MSI creates images from molecules by measuring their mass-to-charge ratios with mass spectrometry. This shift from photons to molecules provides a powerful new view of biology but also raises fundamental challenges at the interface of analytical chemistry and photonics. In this talk, I will discuss how specifically engineered infrared laser sources, tuned to vibrational resonances such as the O?H stretch at 2.94 μm, can be engineered as precise ablation sources for MSI. By controlling wavelength, pulse duration, and fluence, we have demonstrated imaging at sub-cellular ‘resolutions’ (2 μm pixels) with enhanced molecular sensitivity, and directly visualized how plume dynamics govern the ion signal captured in the mass spectrometer. Beyond the technical results, I will reflect on the broader opportunities and challenges of navigating a path that merges ultrafast photonics with analytical chemistry, an often difficult but highly rewarding journey that is opening new routes toward high-resolution molecular pathology, high throughput sample screening, and laser-guided surgery.
使用言語：English/英語
紹介教員：井手口 拓郎
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